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In many cases, drugs are Harmless to work with for one yr when they’re dispensed from a pharmacy. You'll want to take the medication just before its expiration date and toss it away following it expires.g., creatinine clearance < 30 mL/min), and concomitant usage of erythromycin or powerful CYP3A4 inhibitors, plasma amounts of sildenafil at 24 hr